Most bacterial species, pathogens or commensals, are clonal in nature, represented by the strains with distinct phenotypes circulating as a limited number of genetically related (i.e. clonal) lineages. The stability of such (adapted) clonal lineages has been demonstrated to be strong enough, both temporally and spatially, to decipher consistent clonal association with important traits like specific virulence potentials or antibiotic resistance profiles. A couple of the planned projects:
(a) Identification of clonal signatures for antibiotic resistance in enterobacterial pathogens.
(b) Adaptive role of truncation mutations in Salmonella virulence evolution.