The change in technology has not only enhanced the operational conditions and user friendliness but transformed the attitude and strategy of modern functional role. This necessitates scientific research, system design, product development resulting in integration of multidisciplinary technologies. This also needs structured modular architecture for a successful outcome. The various disciplines of sciences like electronics, software, sensors, materials etc. are progressing at a fast pace. The technical institutes are focusing accordingly. However, the industry who are mainly responsible for product design, development and customer satisfaction finds gap among the fresh and midlevel engineers about the understanding of multidisciplinary integration concept. There is difficulty to play proper role in industrial environment especially in system design, product development and final release and acceptance. In view of this changing scenario, the main objective of the Centre for Interdisciplinary Sciences (CIS) of JIS Institute of Advance Studies and Research (JISIASR) is to fill this gap with the support of industry to provide latest technology based integrated interdisciplinary education to the country’s youth.
Background and Themes:
Centre for Interdisciplinary Sciences offers an advanced scope of research and educational curriculum where the basic science meets with the technology to address some very interesting and pertinent issues for present society. This centre establishes a strong connection between theoretical and application oriented research areas of global perspective. Interdisciplinary research has emerged as a tool for breaking down departmental barriers through a novel approach of collaborative research facilitates that would not be possible within a confined idea of a particular discipline.
Core Research Areas:
Some specific research areas of CIS are: Sensor Technology & IoT, Nanoscale Materials, Polymer Science and Technology, 3D Printing, Biomaterials, Devices and Systems, Engineering Design, Energy, and Water.
Advanced Materials/ Smart Sensors/ Polymer Science and Technology/ Nanoscience and Technology/ Drug Delivery & Theranostatics.
*Highly motivated and bright students are requested to communicate directly with the faculty members of this centre for possible PhD position in the relevant areas
Master degree program is the key to specialization for future research and to develop required skills to meet the demand of the related industries. JISIASR Kolkata offer the following master programs where the subjects are chosen to support the fresh graduates to make themselves skillful and qualified for present job market and future research.
Eligibility: B.Sc. (with minimum 50% marks or equivalent CGPA) in Chemistry / Physics / Biochemistry / Life Sciences / any other relevant subject.
** All the above master programs are planned to provide a great exposure for the students to strong theoretical concept along with sound practical skill.
CIS Advanced Polymer Sc. Brochure
In addition to the above programs CIS also offers-
A six months certificate program in 3D printing:
Eligibility: Any Science/Engineering graduate student can apply
Research group of Dr. Prosenjit Saha:
Electrospinning and 3D Bioprinting of Biopolymers for Artificial Skin and Bone Implant:Research on development and fabrication of polymer based artificial skin and implants for tissue engineering applications is focused using advanced materials and fabrication technology. Chitin or chitosan can be used to prepare biocompatible materials for artificial skin, or organs. Eelectrospun chitin nanofibers can be used as reinforcement of high performance non-toxic fibrous scaffolds. Such scaffold could be an alternate to native skin regarding substantial unique properties. 3-D bioprinted chitin can also be used for highly specific and sensitive smart skin.
3D Bioprinting Unit
Flow Diagram of Formation of Artificial Skin by Electrospinning and 3D Bioprinting
Inexpensive water filter:Another team under Dr. Prosenjit Saha is working on the removal of organic halides and pesticides from drinking water using chemically / biologically trans-esterified waste biomass. Water with elevated halide content was passed through a fixed bed of treated biomass (jute, banana, water-hyacinth, elephant grass) and the halide was partly trapped within the biomass. An outlet effluent with acceptable halide content was obtained.
Flow Diagram of the Filter
Inexpensive water filter:
Iron-functionalized reduced graphene oxide (fRGO)-coated sand was used for the adsorption of natural organic matter, such as fulvic acid (FA), from synthetic water A novel synthesis route was achieved to prepare an fRGO nanocomposite FTIR, optical microscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM), and atomic force microscopy (AFM) were applied to investigate the morphologies and structures of fRGO The effects of pH of the FA solution and the adsorbent dose (0.5–2.5 mg g-1 ) of fRGO were further evaluated for the determination of a possible removal mechanism. The π– π interaction between the carbon atoms of FA and fRGO and electrostatic interaction
Flow Diagram of Fulvic Acid Removal by Iron Fictionalized Reduced Graphene
An advanced and interesting research under the supervision of Dr. Prosenjit Saha is going on at JISIASR-Kolkata on the development of natural fiber based green composites those will be resistant to catch fire after applying eco-friendly surface treatment. The resistance to catch fire for such composites is expected to enhance 3-4 times compared to untreated fiber based composites. Mainly jute, sisal, coconut fibers are used for making such fire resistant composites. Natural polymers present within the above fibers are cellulose, lignins, and hemicelluloses. The surfaces of such polymers are being altered to enhance the fire resistance.
Flow Diagram of Fulvic Acid Removal by Iron Fictionalized Reduced Graphene
Research group of Dr. Subhankar Singha:
Smart Sensors & Advanced Materials: below diagram by mentioning the associated ongoing researches. It covered the basic research on biosensing and bioimaging through the development of 1) Fluorescent Sensors/Probes for Biosensing, and 2) Fluorescent Materials for Bioimaging. Those basic researches on sensing and imaging materials are currently using for the application oriented research towards- 3) Development of sensor device for quality control of environmental samples, and 4) Drug Delivery and Theranostics for Cancer.
In short, the research in this group is mainly focused on the development of novel fluorescent sensing materials and probes/sensors/assay kits, and their application for bio-sensing and patho-biological analysis, as well as innovation of sensor technology (in combination with electronics and IoT) for global sustainability.
Advanced Fluorescent Materials for Bioimaging:Fluorescence bioimaging combined with fluorescence microscopy technology has revolutionized human ability to study and visualize complex life phenomena at the molecular level to understand the cellular events with least ambiguity. The continuous synergistic growth of bioscience and medical science demands for better diagnostic tools/systems; resulting the introduction of two-photon fluorescence bioimaging recently based on two-photon induced excitation technology. Two-photon bioimaging is highly advantageous to provide 3D imaging of living specimens (including animal tissues) with sub-micrometer resolution down to the depth of a millimeter with high-sensitivity and reduced photo-damage using low energy near-infrared (NIR) light. The promising features of two-photon imaging in turn have inspired a quest for two-photon active fluorophores and probes.
Herein, several strategies for two-photon bioimaging has been explored to tackle the limitations of the existing bioimaging materials. This fundamental research provides essential guidelines for the development of novel two-photon materials/fluorophores with high emission intensity (Chem. Sci., 2015, 6, 4335) as well as emission at long wavelength to avoid the intrinsic autofluorescence from biomolecules (J. Am. Chem. Soc. 2015, 137, 6781; Chem. Commun., 2012, 48, 10243; Chem. Sci., 2019, 10, 9028). Accordingly, those newly developed materials act as excellent contrast agents in two-photon bioimaging.
Smart Fluorescence Sensors/Probes for Sensing:Monitoring and visualization of complex physiological or cellular processes using fluorescence probes/biosensors is the ultimate goal of fluorescence bioimaging. Herein, several fluorescence probes/biosensors have been developed for the detection and analysis of biomolecules (or biomarkers) to monitor several physiological processes and diagnose disease (Acc. Chem. Res., 2019, 52, 2571). Several probes were developed to selectively target various biologically relevant analytes such as biothiols, hydrogen sulfide, formaldehyde, hypochlorous acid, zinc, pyrophosphate and fluoride ions (Dyes and Pigments, 2013, 99, 308; Anal. Chem., 2015, 87, 1188; Chem. Commun., 2016, 52, 124; Org. Biomol. Chem., 2012, 10, 8410; Chem. Commun., 2012, 48, 10243; Chemical Society Reviews, 2015, 44, 4367) as well as disease biomarkers such as amyloid-beta (for Alzheimer’s disease; Journal of the American Chemical Society, 2015, 137, 6781) and dipicolinate (for Anthrax; Asian Journal of Organic Chemistry, 2017, 6, 1257). Each of those probes were further applied to visualize various biological processes through two-photon bioimaging. A simple fluorescence assay kit for detection of antibiotic (ciprofloxacin) in urine has been developed, which is highly promising to avoid the drug overdoses in human body and reduce the drug contamination in environment (Sensors, 2016, 16, 2065).
The research of this sensing field has been further extended towards more rigorous applications in chemical biology as well as for environmental analysis (Anal. Chem. 2017, 89, 3724; Chem. Comm., 2017, 53, 10800; J. Mater. Chem. B, 2018, 6, 4446; Sensors and Actuators B-Chemical, 2018, 277, 576; Tetrahedron Lett., 2018, 59, 49; J. Anal. Method Chem., 2018, 2654127; Sensors and Actuators B-Chemical, 2019, 279, 204) through research collaboration with several renowned research groups (Cell Metab., 2017, 25, 1320; Phy. Chem. Chem. Phy., 2017, 19, 12237; RSC Adv., 2019, 9, 35549; Chem.–European Journal, 2019, 9728; Langmuir 2019, 35, 13, 4682) from academic institutions such as Harvard University (USA), Singapore National University (Singapore), S N Bose National Centre for Basic Sciences (India), West Bengal State University (India).
**One of the developed fluorescent probes for hydrogen sulfide is also commercialized by Merck Inc., USA.
Drug Delivery and Theranostics for Cancer and Arthritis:Theranostics is a treatment strategy combining therapeutics with diagnostics. It associates a diagnostic test that identifies the disease, and following targeted drug delivery and therapy based on the test results. For such purposes, our research is aimed on developing smart materials towards a one-step strategy for fluorescence imaging guided disease diagnosis, multiconditional target specific quantitative drug delivery, and visualization/monitoring the therapy process, all at the same time. Currently, the research on drug delivery and theranostics in our group is mainly focusing towards the two most common diseases- Cancer and Arthritis. A research grant (approx. USD 250,000) was also approved from National Research foundation (NRF) of Korea in 2018 to peruse the research on “Hydrogen sulfide triggered drug delivery for theranostics”.
Existing Research Facilities and Collaborations:
The centre has a strong academic and research collaborations with several leading national and international institutes and industries such as-
- Indian Institute of Technology (IIT) Kharagpur
- Mahatma Gandhi University (MGU), Kerala
- National Institute of Pharmaceutical Education And Research (NIPER) Kolkata
- S. N. Bose National Centre for Basic Sciences, Kolkata
- Confederation of Indian Industry (CII)
- Indian Paint Association (IPA)
- TCG Lifesciences Private Limited (Chembiotek)
- Leibniz-Institut für Polymerforschung (IPF) Dresden, Germany
- Pohang University of Science & Technology (POSTECH), South Korea
- University of Lyon, France
Ongoing Funded Research Projects:
|Sl. No||Project Title||Principal Investigator||Funding Agency|
|Development of smart skin with natural polymer by 3D printing and electrospinning||
|Dr. Prosenjit Saha||
|DST Inspire-Faculty Scheme|
|Engineered Biomimetic Cellulose Nano-scaffold for Skin and Bone Replacement||
|Dr. Prosenjit Saha||
|DST-SERB under Early Career Research|
|Development of nanofiber reinforced plant polymer based durable, fire retardant biocomposites||
|Dr. Prosenjit Saha||
|DST-SEED under Young Scientist and Technologist|
|Hydrogen sulfide triggered drug delivery for theranostics||
|Dr. Subhankar Singha||
|National Research Foundation (NRF), Korea|