Dr. Nibedita Pradhan

Current Designation: Assistant Professor, Centre for Interdisciplinary Sciences, JISIASR, (August 2025)
E-mail ID: pnibedita11@gmail.com; nibedita.cis@jisiasr.org
Google Scholar Link: https://scholar.google.com/citations?user=rRujI4wAAAAJ&hl=en

Ph.D. position available: Highly motivated NET/GATE qualified or self-funded candidates with Biology/Chemistry/Materials Science or interdisciplinary background are encouraged to contact Dr. Nibedita for pursuing Ph. D on full-time or part-time basis in the interface of Nano-bioscience.

Domain of Interest: Nanobiotechnology, Designed nanoparticle as therapeutics, Nano bioconjugate, Nanocomposite and Nano-vesicle, Nanoparticle-protein interaction, Amyloid inhibitor, disruptor and aggregate cleaner nanoparticle, Natural product integrated nanoparticle

Research Focus: We intend to work at the interface of Biology, chemistry and material Science. We design nanoparticle, nanocomposite and nano bioconjugate for wide-range of applications such as therapeutics for proteinopathy related neurodegenerative diseases and cardiovascular disease, cancer and alternative antibiotics. In addition, exploration of plant-based natural products and nano-formulation of phytocompounds for hypertension management, cardiovascular disease, neurodegenerative disease and anti-cancer. Development of sustainable polymer nanocomposite-based material for active packaging, smart bioplastic, wound healing material is also our area of interest.

Academic Profile

• Present Position: Assistant Professor (August 2025-Till Date), Centre for Interdisciplinary Sciences, JIS Institute for Advanced Science & Research, Howrah, India

Position Held

• Assistant Professor (May 2024-July 2025), Department of Biotechnology and Genetics, MSRCASC, Bangalore, India
• Assistant Professor (Jan 2023-April 2024), School of Life Science, Kristu Jayanti College (Autonomous), Bangalore, India
• Principal Investigator (Jan 2020-August 2022), SERB-National Post Doctoral Fellow, School of Bioscience, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal, India

Academic Background:

• National Post-Doctoral Fellow (Mentor: Prof. Nihar Jana): January, 2020 – August, 2022;School of Bioscience, IIT-Kharagpur, Kharagpur, West Bengal, India.
• Post-Doctoral Fellow (Advisor: Prof. Nikhil Ranjan Jana): March, 2018 – December, 2019;Indian Association for the Cultivation of Science, Kolkata,India.
• Ph. D (Advisor: Prof. Nikhil Ranjan Jana): March, 2013 – March, 2018;Indian Association for the Cultivation of Science, Kolkata,India.
• Ph.D. Thesis title: Detection and inhibition of amyloid fibrillation using functional molecule and nanoparticle
• MSc (2011) Biotechnology Jadavpur University, Kolkata,India.
• BSc (2009) Chemistry Calcutta University, Kolkata, India.

List of Publications

[1] Nibedita Pradhan*, Santanu Shaw, Nihar R Jana, Nanoascorbate Promotes Clearance of Mutant Huntingtin Aggregates via Restoration of Blocked Autophagy. ACS Applied Nano Materials, 2025, 8, 16, 7974-7988. https://doi.org/10.1021/acsanm.5c00240.

[2] Mayank Pandey, Nibedita Pradhan, Mahmoud H. Abu Elella, Edwin Makhado, Moshera Samy, Orebotse Joseph Botlhoko, Dalia Allouss. Frontiers in Polymer/Carbon Dots Nanocomposites: Recent Advances in Synthesis and Diverse Applications, Surfaces and Interfaces, 2025, 106101. https://doi.org/10.1016/j.surfin.2025.106101.  

[3] Nibedita Pradhan*, Nihar Ranjan Jana. Design of Nanomodulators That Target Alzheimer’s Disease: A Review. ACS Applied Nano Materials, 2024, https://doi.org/10.1021/acsanm.3c04846.

[4] Mahima Misti Sarkar^#, Nibedita Pradhan^#, Rewaj Subba, Puja Saha, Swarnendu Roy. Sugar-terminated carbon-nanodots stimulate osmolyte accumulation and ROS detoxification for the alleviation of salinity stress in Vigna radiate. Scientific Reports, 2022, 12, 17567, https://doi.org/10.1038/s41598-022-22241-w. (^#Equal first author)

[5] Nibedita Pradhan, Nihar R. Jana, Nikhil R. JanaInhibition of Protein Aggregation by Iron Oxide Nanoparticles Conjugated with Glutamine-and Proline-Based Osmolytes. ACS Applied Nano Materials 2018, 1, 1094-1103.

[6] Nibedita Pradhan, Koushik Debnath, Suman Mandal, Nihar R. Jana, Nikhil R. Jana. Anti-amyloidogenic Chemical/Biochemical-Based Designed Nanoparticle as Artificial Chaperone for Efficient Inhibition of Protein Aggregation. Biomacromolecules, 2018, 19, 1721–1731.

[7] Koushik Debnath, Nibedita Pradhan, Brijesh K Singh, Nihar R. Jana, Nikhil R. Jana. Poly (trehalose) Nanoparticles Prevent Amyloid Aggregation and Suppress Polyglutamine Aggregation in a Huntington’s disease Model Mouse. ACS Applied Materials & Interfaces 2017, 9, 24126-24139.

[8] Nibedita Pradhan, Shashi Shekhar, Nihar R. Jana, Nikhil R. Jana. Sugar-Terminated Nanoparticle Chaperones are 10²–10⁵ Times Better than Molecular Sugars in Inhibiting Protein Aggregation and Reducing Amyloidogenic Cytotoxicity. ACS Applied Materials & Interfaces 2017, 9, 10554-10566.

[9] Anirban Ghosh, Nibedita Pradhan, Swapna Bera, Aritreyee Datta, Janarthanan Krishnamoorthy, Nikhil R Jana & Anirban Bhunia. Inhibition and degradation of amyloid beta (Aβ40) fibrillation by designed small peptide: a combined spectroscopy, microscopy, and cell toxicity study. ACS Chemical Neuroscience 2017, 8,718-722.

[10] Nibedita Pradhan, Shashi Shekhar, Nihar R. Jana, Nikhil R. Jana. Detection and monitoring of amyloid fibrillation using a fluorescence “switch-on” probe. ACS Applied Materials & Interfaces 2015, 7, 25813-25820.

[11] Susanta Kumar Bhunia, Nibedita Pradhan, and Nikhil R. Jana. Vitamin B1 Derived Blue and Green Fluorescent Carbon Nanoparticles for Cell-Imaging Application. ACS Applied Materials & Interfaces 2014, 6, 7672-7679.

Book Chapter

[1] Fundamental photophysical properties of fluorescent carbon dots and their applications in metal ion sensing and bioimaging. Soumita Mukhopadhyay, Tapan Kumar Si, Nibedita Pradhan, Fundamentals and Properties of Multifunctional Nanomaterials 2021, ISBN 9780128223529, Fundamentals and Properties of Multifunctional Nanomaterials’-1^st edition, Elsevier. Edited by Professor Sabu Thomas, Vice-Chancellor Mahatma Gandhi University.

[2] Design of therapeutic nanomaterials for amelioration of Alzheimer’s disease. Nibedita Pradhan, Tapan Kumar Si, Theranostic Applications of Nanotechnology in Neurological Disorders 2024, ISBN 978-981-99-9509-7, Springer Nature. Edited by Dr. Akash Gautam, University of Hyderabad.

Recent Highlights

Shaastra (science and technology magazine published by Indian Institute of Technology Madras), highlighted our nanoascorbate article, published by ACS Applied Nanomaterials as News in Brief in May 2025 edition, Cleaning up faulty proteins.

Awards and Achievements:

• Awarded SERB-National Post-Doctoral Fellowship 2019 in Life Science (IIT-Kharagpur, School of Bioscience, West Bengal).
• Professor Asima Chatterjee Young Scientist Award 2018, Professor Asima Chatterjee Foundation, Calcutta University.
• Reviewer of ACS Applied Biomaterials and Engineering, ACS applied Nano Materials, Bentham Science Publisher.
• Qualified CSIR-National Eligibility Test, GATE.
• Best Oral Presentation in National Conference ‘Current Trends in Biological and Health Sciences 2024’, 11-12 December 2024, REVA University,Bangalore, India.

Conference Presentation:

• Nibedita Pradhan; Nanoascorbate, Promotes Clearance of Mutant Huntingtin via Up-regulating Autophagy. ‘Current Trends in Biological and Health Sciences 2024’, REVA University, Bangalore, India, 11–12 December 2024. (Awarded for Best Oral Presentation)
• Invited as speaker in 4th World Symposium on Material Sciences and Engineering 2025, Singapore, SMSE2025 Organizing Committee.
• Invited as speaker and organizing committee member at Global Summit on Materials Science and Nanoscience (Materials2025), Frankfurt, Germany. Materials2025 Organizing Committee.
• Invited as speaker in 10th Neurological Disorders Summit 2025, Frankfurt, Germany. NDS2025.
• Nibedita Pradhan; Invited Lecture on “Designed Nanomodulators Targeting Neurodegenerative Diseases” in Research Colloquium-2024 ‘VIGNANA VICINTANA’, Department of Life Sciences, Kristu Jayanti College, Bengaluru, Karnataka, India, 10 January 2024.
• Arya Arun Kumar, Chandni Gupta, K. Swathi Srujana, Nibedita Pradhan; Unmasking Manganese: Homeostasis, Neurotoxicity, and Case Insights. Trace Elements in Man and Animal 18–2024, India Pre-Conference Workshop organized by M S Ramaiah College of Arts, Science and Commerce (Autonomous), Bangalore, India, 6 November 2024.
• Nibedita Pradhan; Invited Short Lecture on “Designed Nanochaperones for Inhibition of Amyloid Fibrillation” in Professor Asima Chatterjee Centenary Seminar (PACCS-2018) on Recent Inventions in Chemical and Allied Science, organized by Prof. Asima Chatterjee Foundation, University of Calcutta, Kolkata, India, 23 September 2018.
• Nibedita Pradhan, Nikhil R. Jana; Chemically Designed Nanoparticle for Prevention of Neurodegenerative Diseases. Nano India National Conference 2019, Department of Science and Technology, International and Inter University Centre for Nanoscience and Nanotechnology, Mahatma Gandhi University, Kottayam, Kerala, India, 26–27 April 2019.
• Nibedita Pradhan, Nikhil R. Jana; Nanoparticle Form of Anti-amyloidogenic Molecule up to 100,000 Times Enhanced Performance in Inhibiting Protein Aggregation. National Conference “Young Scientist Colloquium 2017”, Material Research Society of India (Kolkata Chapter), IIEST Shibpur, Howrah, India, 11 October 2017.
• Nibedita Pradhan, Nikhil R. Jana; Fluorescence “Switch-On” Probe for Monitoring of Amyloid Fibrillation. International Seminar on Current Thoughts in Cell Sciences, Centre for Research in Nanoscience and Nanotechnology, University of Calcutta, Kolkata, India, 8 November 2015.

Project as Principal Investigator

• Understanding the Mechanism of Clearing Neurotoxic Protein Aggregates via Autophagy Modulation by Designed Nanochaperone. (2019-2022).
• Principal Investigator: Dr. Nibedita Pradhan; Funding Agency: SERB; Status:    Completed.
• Synthesis of Nanoparticles with Anti-hypertensive Properties from Indian medicinal plant and Evaluation of Cardio-protective Activity Using Zebrafish Model. (2023-2025). Principal Investigator: Dr. Nibedita Pradhan; Funding Agency: Sodh Pravartan Research Grant, Bodhi Niketan Trust, Bangalore. Status: Completed. 
• Fabrication of Biodegradable Polymer Nanocomposite Film for Food Packaging. Principal Investigator: Dr. Nibedita Pradhan.