Dr. Pooja Ghosh

Assistant Professor
Centre for Interdisciplinary Sciences (CIS), JISIASR
M.Sc (Vidyasagar University)
Ph.D (IIT Kharagpur)
Postdoc (IISER Kolkata)
Guest Scientist (Karlsruhe Institute of Technology, Karlsruhe, Germany)

Email id: poojaghosh@jisiasr.org

Google Scholar: https://scholar.google.com/citations?user=bsy79cgAAAAJ&hl=en

ResearchGate: https://www.researchgate.net/profile/Pooja-Ghosh

Linkedin: https://www.linkedin.com/in/pooja-ghosh-54094a94/

Ph.D. position available: Highly motivated NET/GATE qualified or self- funded candidates with Chemistry/Materials Science/Nanotechnology background are encouraged to contact Dr. Pooja Ghosh for pursuing Ph.D on full-time or part-time basis.

Post-doctoral position: Self-funded (NPDF or similar self-funded position) candidates with a background in protein aggregation/nanomaterials/drug delivery or related areas are encouraged to apply directly to the above email ID.

Academic Background:

Ph.D.: Biophysical Chemistry             

Indian Institute of Technology (IIT) Kharagpur, Kharagpur, West Bengal, India

Advisors: Professor Swagata Dasgupta

Dissertation Title: Protein- and polymer-based nanoparticles for delivery of flavonoids

MSc: Department of Chemistry; Vidyasagar University, Midnapore, West Bengal, India

BSc: Department of Chemistry; Midnapore College, Vidyasagar University, Midnapore, West Bengal, India

Professional Experiences

July 2023- Present: Assistant Professor, JIS Institute of Advanced Studies and Research (JISIASR), JIS University, Kolkata, India

2022: Guest Scientist, Karlsruhe Institute of Technology, Karlsruhe, Germany

2021-2023: DBT Research Associate, IISER Kolkata, Kalyani, West Bengal, India

2019-2021: Research Associate, DST-RFBR Fellow, IISER Kolkata, Kalyani, West Bengal, India

Research Interest:

• Nanoparticles and drug delivery
• Amyloid protein aggregation
• Protein and ligand interaction study
• Protein chemistry
• Polymer chemistry
• Spectroscopic techniques
• Biophysical chemistry

Research Focus:

Designing Nanoparticulate Systems for Drug Delivery

Design of novel protein/polymer-based nanoformulations for delivery of biomolecules to the intended target region, hence augmenting their antibacterial and anticancer characteristics. These delivery systems have the advantages of regulated release, precise targeting, biodegradability, and efficient encapsulation.

Interaction of Nanomaterials/Ligands with Biological Systems

Our focus is on observing the interactions between the synthesized nanomaterials and various biomacromolecules found in the bloodstream. Any bioactive substance that enters the circulation or systems based on nanomaterials interacts with a variety of biomacromolecules, including lipids, nucleic acids, and serum proteins. The release and transport characteristics of pharmaceuticals are impacted by this kind of interaction. Therefore, it is crucial to look at how proteins, lipids, and nucleic acids interact with systems based on nanoparticles.

Design of Novel Therapeutic Agents for Modulating Protein Aggregation Process

To gain an understanding of the aggregation process mechanism, it would be helpful to know the specifics of how polymers/therapeutic agents interact with amyloid aggregates at various fibrillation phases. This can be used as a useful model to create innovative biopolymer-based inhibitors/anti-amyloidogenic agents that effectively treat neurodegenerative illnesses/non-neuropathic disorders and advance our understanding of protein aggregation.

Journal Publications:           

• Ghosh, P.;* Mondal, A.; De, P. Polymeric Materials as a Promising Platform for Suppressing Protein Aggregation Process. Current Indian Science 2024, 2, 1-15.
• Nayak, K.; Ghosh, P.; Barman, S.; Sudhamalla, B.; Theato, P.; De, P. Amyloid β-Peptide Segment Conjugated Side-Chain Proline-Based Polymers as Potent Inhibitors in Lysozyme Amyloidosis. Bioconjugate Chem. 2024, 35, 312-323.
• Bera, A.;^# Ghosh, P.;^# Goswami, K.; De, P. Amino Acid-Based Polymer-Coated Silver Nanoparticles as an Insulin Fibril Inhibitor. ACS Applied Nano Materials 2023, 6, 8705-8716. [# Equal author]
• Bera, A.;^# Ghosh, P.;^# Ghosh, S.; Mukherjee, A.; De, P. Antioxidant Polymers with Enhanced Neuroprotection Against Insulin Fibrillation. Macromolecular Bioscience 2023, Just Accepted. [# Equal author]
• Ghosh, P.; Parveen, S.; Chaudhury, S.; Dasgupta, S. Polyphenol Loaded Nanoparticles as Antiglycating Agents: A Case Study with Human Serum Albumin. AsiaChem 2023, 3, 66-77.
• Bera, A.;^# Ghosh, P.;^# Barman, S.; Bhattacharya, S.; Sudhamalla, B.; Goswami, K.; De, P. Insulin Fibril Inhibition Using Glycopolymeric Nanoassemblies. Biomaterials Science 2023, 11, 3574-3588. [# Equal author]
• Singh, A.; Ghosh, P.; Mukherjee, S.; Ojha, A. K.; Hansda, A.; Choudhury, P.; Halder, S.; Sharma, S.; Mukherjee, G.; Dasgupta, S.; Chaudhury, K. Transition metallo-curcumin complexes: a new hope for endometriosis? Mater. Chem. B, 2022, 10, 9682-9698.
• Dey, A.; Haldar, U.; Rajasekhar, T.; Ghosh, P.; Faust, R.;* De, P.* Polyisobutylene-based glycopolymers as potent inhibitors for in vitro insulin aggregation. Mater. Chem. B 2022, 10, 9446-9456.
• Ghosh, P.; Bag, S.; Roy, P.; Chakraborty, I.; Dasgupta, S. Permeation of flavonoid loaded human serum albumin nanoparticles across model membrane bilayers. J. Biol. Macromol. 2022, 222, 385-394.
• Bera, A.; Mukhopadhyay, D.; Goswami, K.; Ghosh, P.;* De, R.;* De, P.* Fatty Acid-Based Polymeric Micelles to Ameliorate Amyloidogenic Disorders. Biomaterials Science 2022, 10, 3466-3479.
• Ghosh, P.; Bag, S.; Parveen, S.; Subramani, E.; Chaudhury, K.; Dasgupta, S. Nanoencapsulation as a Promising Platform for the Delivery of the Morin-Cu(II) Complex: Antibacterial and Anticancer Potential, ACS Omega 2022, 7, 7931-7944,
• Mondal, A.; Khan, M. E. H.; Ghosh, P.;* De, P.* Future Direction of Designing Antioxidant Polymers in Modulating Protein Aggregation Process. Journal of Molecular and Engineering Materials 2022, DOI: https://doi.org/10.1142/S2251237321400013
• Sahoo, S.; Ghosh, P.; Khan, M. E. H.; De, P.* Recent Progress in Macromolecular Design and Synthesis of Bile Acid‐Based Polymeric Architectures. Chem. Phys. 2021, 223, 2100414.
• Bera, A.; Sahoo, S.; Goswami, K.; Das, S. K.; Ghosh, P.;* De, P.* Modulating Insulin Aggregation with Charge Variable Cholic Acid-Derived Polymers. Biomacromolecules 2021, 22, 4833-4845.
• Nayak, K.;^# Ghosh, P.;^# Khan, M. E. H.; De, P. Side‐Chain Amino Acid‐Based Polymers: Self‐Assembly and Bioapplications. Int. 2021, 71, 411-425. (#Equal contribution)
• Ghosh, P.; Bera, A.; Bhadury, P.; De, P. From Small Molecules to Synthesized Polymers: Potential Role in Combating Amyloidogenic Disorders. ACS Chem. Neurosci. 2021, 12, 1737–1748.
• Sahoo, S.; Ghosh, P.; Banerjee, S.; De, P. Recent Advances in Biomedical Applications of Cholic Acid-Based Macromolecules. ACS Appl. Polym. Mater. 2021, 3, 1687-1706.
• Ghosh, P.; Bera, A.; De, P. Current Status, Challenges and Future Directions in the Treatment of Neurodegenerative Diseases by Polymeric Materials. Indian Chem. Soc. 2021, 98, 100011.
• Ghosh, P.; De, P. Modulation of Amyloid Protein Fibrillation by Synthetic Polymers: Recent Advances in the Context of Neurodegenerative Diseases. ACS Appl. Bio Mater. 2020, 3, 6598–6625.
• Ghosh, P.; Bera, A.; Ghosh, A.; Bhadury, P.; De, P. Side-Chain Proline-Based Polymers as Effective Inhibitors for in vitro Aggregation of Insulin. ACS Appl. Bio Mater. 2020, 3, 5407–5419.
• Parveen, S.; Ghosh, P.; Mitra, A.; Gupta, S.; Dasgupta, S. Preparation, characterization, and in vitro release study of curcumin-loaded cataractous eye protein isolate films. Emergent Materials, 2019, 2, 475-486.
• Roy, P.; Parveen, S.; Ghosh, P.; Ghatak, K.; Dasgupta, S. Flavonoid loaded nanoparticles as an effective measure to combat oxidative stress in Ribonuclease A. Biochimie. 2019, 162, 185-197.
• Ghosh, P.; Patwari, J.; Dasgupta, S. Complexation with Human Serum Albumin Facilitates Sustained Release of Morin from Polylactic-Co-Glycolic Acid Nanoparticles. Phys. Chem. B 2017, 121, 1758-1770.
• Ghosh, P.; Bag, S.; Singha Roy, A.; Subramani, E.; Chaudhury, K.; Dasgupta, S. Solubility enhancement of morin and epicatechin through encapsulation in an albumin based nanoparticulate system and their anticancer activity against the MDA-MB-468 breast cancer cell line. RSC Adv. 2016, 6, 101415-101429.
• Ghosh, P.; Roy, A.S.; Chaudhury, S.; Jana, S.K.; Chaudhury, K.; Dasgupta, S. Preparation of albumin-based nanoparticles for delivery of fisetin and evaluation of its cytotoxic activity J. Biol. Macromol. 2016, 86, 408-417.
• Singha Roy, A.; Samanta, S.; Ghosh, P.; Tripathy, D.R.; Ghosh, SK.; Dasgupta, S. Cell cytotoxicity and serum albumin binding capacity of the morin-Cu(II) complex and its effect on deoxyribonucleic acid. BioSyst. 2016, 12(9), 2818-2833.
• Singha Roy, A.; Ghosh, P.; Dasgupta, S. Glycation of human serum albumin affects its binding affinity towards (-)-epigallocatechin gallate. Incl. Phenom. Macrocycl. Chem. 2016, 85, 193-202.
• Chaudhury, S.; Ghosh, P.; Parveen, S.; Dasgupta, S. Glycation of human γB-crystallin: A biophysical investigation. Int J Biol Macromol. 2016, 96, 392-402.
• Singha Roy, A.; Ghosh, P.; Dasgupta, S. Glycation of human serum albumin alters its binding efficacy towards the dietary polyphenols: a comparative approach. J Biomol Struct Dyn. 2016, 34(9), 1911-8.
• Singha Roy, A.; Ghosh, P. Characterization of the binding of flavanone hesperetin with chicken egg lysozyme using spectroscopic techniques: effect of pH on the binding. Incl. Phenom. Macrocycl. Chem. 2016, 84, 21-34.
• Das, S.; Ghosh, P.; Koley, S.; Singha Roy, A. Binding of naringin and naringenin with hen egg white lysozyme: A spectroscopic investigation and molecular docking study. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2018, 192, 211-221.
• Das, S.; Karn, A.; Sarmah, R.; Rohman, M.A.; Koley, S.; Ghosh, P.; Singha Roy, A. Characterization of non-covalent binding of 6-hydroxyflavone and 5,7-dihydroxyflavone with bovine hemoglobin: Multi-spectroscopic and molecular docking analyses. J Photochem Photobiol B. 2017, 178, 40-52.
• Majumdar, R.; Bag, B.G.; Ghosh, P. Mimusops elengi bark extract mediated green synthesis of gold nanoparticles and study of its catalytic activity. Applied Nanoscience. 2015, 6, 521-528.

Conferences & Workshops Attended:

• One Day Symposium on “Exploring Career Paths in Basic and Bio-Sciences” held on 5th April, 2024 at Bhairab Ganguly College, North 24 Parganas, West Bengal, India
• SERB Sponsored Two-Day National Workshop on “Recent Trends in Anticancer Drug Development and Theranostics Application” held during April 2-3, 2024 organized by Centre for Interdisciplinary Sciences (CIS), JIS Institute of Advanced Studies and research (JISIASR), JIS University, Kolkata, India
• International conference on advances in polymer science and rubber technology (APSRT 2019) held during 24th-27th September 2019 at IIT Kharagpur, India
• Symposium on Polymer Science (SPS-2019) jointly organized by SPSI (Kolkata Chapter) & CAFM, IISER Kolkata held on July 05-06, 2019 at IISER Kolkata, India
• 253rd American Chemical Society NATIONAL MEETING & EXPOSITION held during April 2-6, 2017 in San Francisco, CA, USA
• 22nd Conference of National Magnetic Resonance Society (NMRS) 2016 organized by Department of Chemistry, IIT Kharagpur held on 18th-21st February, 2016 at IIT Kharagpur, India
• 18th CRSI NATIONAL SYMPOSIUM in Chemistry held during February 5-7, 2016 in Punjab University, Chandigarh, India
• Author Workshop on “Scholarly Publishing”, organized by Wiley and Central Library, IIT Kharagpur, held on March 23, 2015 at IIT Kharagpur, Kharagpur, India
• National Symposium on Biophysics & Golden Jubilee Meeting of Indian Biophysical Society (IBS) held during February 14-17, 2015 in Jamia Millia Islamia, New Delhi, India
• One day symposium on Current Trends in Synthetic Organic Chemistry held on January 13, 2015 in IIT Kharagpur, Kharagpur, India
• International Conference on “Light in Chemistry, Materials and Biology (LCMB 2014)”, held during February 24-25, 2014 at IIT Kharagpur, Kharagpur, India
• “Author Workshop jointly organized by Springer and IIT Kharagpur” held on February 12, 2014 at IIT Kharagpur, India
• National Symposium on Molecular Architecture and Assembly in Living System (MADALS-2014) held during February 7-10, 2014, jointly organized by Indian biophysical Society (IBS) and Saha Institute of Nuclear Physics (SINP), at SINP, Kolkata, India
• ACS on Campus event held on November 25, 2013 at IIT Kharagpur, India
• One Day International Symposium on ‘Frontiers in Chemical Sciences-2012′ organized by Department of Chemistry and Chemical Technology, Vidyasagar University, Midnapore, India held on 21st March, 2012

Awards & Achievements:

• Awarded Young Researcher Award 2022, by InSc International Publishers.
• Awarded most coveted women inspiration award “Global Women Inspiration Awards & Conclave 2022”
• Awarded International Excellence Fellowship in 2022.
• Awarded DBT RA fellowship in 2021.
• Reviewer of Journal of Macromolecular Science, Part A: Pure and Applied Chemistry, ACS Applied Materials & Interfaces, Molecular Pharmaceutics, International Journal of Biological Macromolecules, Scientific Reports and Communications Biology.
• Winning best poster award at international conference, APSRT 2019.
• Gold medal awarded by Vidyasagar University for securing 1st position in M.Sc. (in 2012).
• Gold medal (Scientist Dr. Narayan Chandra Rana memorial medal) awarded by Vidyasagar      University for      standing best student of the      year 2012 in all PG examination in science
• Gold medal (Sucharita Basu memorial medal) awarded by Vidyasagar University for standing 1st among candidates in all PG examinations (in 2012).
• Gold medal (Biswanath De memorial medal) awarded by Vidyasagar University for standing 1st among candidates in M.Sc examination in Chemistry (in 2012).
• Gold medal (Pravabati devi memorial medal) awarded by Vidyasagar University for securing highest marks among the successful candidates in M.Sc examination in Chemistry (in 2012).
• Qualified for the National Eligibility Test (NET) conducted by Council of Scientific and Industrial Research, India (in 2012).
• Qualified for the Graduate Aptitude Test in Engineering (GATE) (in 2012).

Membership:

• Life Member, InSc International Publishers (IIP), Membership ID. 20226YRA29

Sponsored Projects and Grants

• Flavonoid-Conjugated Silver Nanoparticles: A Significant Platform for Amending the Treatment of Systemic Amyloidosis (2024-2027). Status: Ongoing. Funding Agency: WBDST-BT.

Supervising activity:

MS Thesis: 04 (Completed)

MDS: 01 (Ongoing)

PhD: 02 (Ongoing)

Administrative Experience:

• Departmental Exam Coordinator, JIS Institute of Advanced Studies and Research (JISIASR) Kolkata (2023 – Present)