RUKHSANA CHOWDHURY

RUKHSANA CHOWDHURY

JIS Institute of Advanced Studies & research

HC9M+5F2 ARC Water front(N/AC, Ring Rd, GP Block, Sector V, Bidhannagar, Kolkata, West Bengal 700091

Adjunct Professor

Professional engagements

Professor (2019-2023)

School of Biological Sciences

RKM Vivekananda Educational and Research Institute

Belur, West Bengal

Chief Scientist (upto March 2018)

Infectious Diseases and Immunology Division

CSIR-Indian Institute of Chemical Biology

Kolkata

Professor and Coordinator (upto March 2018)

Academy of Scientific and Innovative Research

CSIR

Education

Ph.D, CSIR-Indian Institute of Chemical Biology, Kolkata, India

M.Sc. in Biochemistry, University of Calcutta, India

B.Sc. with Chemistry (Hons), Presidency College, Calcutta, India

Awards/Honours

Fellow, National Academy of Science, India

Fellow, WB Academy of Science and Technology

National Young Woman Bioscientist Award, Department of Biotechnology

Member, Guha Research Conference

Raman Research Fellowship, CSIR

DBT Overseas Associateship

CSIR Young Scientist Award

Associate, Indian Academy of Sciences

Guha Memorial Prize, Calcutta University

Areas of  research interest

  • Infectious Diseases: Vibrio cholerae, Helicobacter pylori
  • Genetic regulation of bacterial pathogenesis
  • Microbiome: Role in health and disease

Selected Publications

Infiltration to infection: Key virulence players of Helicobacter pylori pathogenicity 2024 Bhattacharjee A,  O.S. Sahoo, A Sarkar, S Bhattacharya, R Chowdhury, O Mukherjee

Infection (in press)

Chakraborty P, Chowdhury  R, Bhakta A, Mukhopahyay P, Ghosh S.2021 Microbiology of periodontal disease in adolescents with Type 1 diabetes Diabetes & Metabolic Syndrome: Clinical Research & Reviews 15 : 102333

Jain S, Chowdhury R, Datta M, Chowdhury G, Mukhopadhyay AK. 2019 Characterization of the clonal profile of methicillin resistant Staphylococcus aureus isolated from patients with early post-operative orthopedic implant based infections. Ann Clin Microbiol Antimicrob. doi: 10.1186/s12941-019-0307-z.  

Sengupta C, Mukherjee O, Chowdhury R.   2016  Adherence to intestinal cells promotes biofilm formation in Vibrio cholerae

 J Infect Dis.  214:1571-1578                                                                         

 

 Bhattacharya S, Mukherjee O, Mukhopadhyay AK, Pal AK, Dhar KK and Chowdhury R.  2016   A conserved Helicobacter pylori gene, HP0102, is induced upon contact with gastric

cells and has multiple roles in pathogenicity       

 J Infect Dis.  214:196-204                                                                             

Sengupta C, Ekka M, Arora S, Dhaware PD, Chowdhury R*, Raychaudhuri S* 2016

Cross feeding of glucose metabolism byproducts of  Escherichia coli human gut isolates and probiotic strains affect survival of  Vibrio cholerae

Gut Pathog.   doi: 10.1186/s13099-016-0153-x.                                                        

Baidya AK, Bhattacharya S, Chowdhury R. 2014 Role of the flagellar hook length control protein FliK and sigma-28 in cagA expression in gastric cell adhered Helicobacter pylori.

J. Infect Dis  (IF 6.34)                                                                                    

Sengupta C, Ray S, Chowdhury R. 2014. Fine tuning of virulence regulatory pathways in enteric bacteria in response to varying bile and oxygen concentrations in the gastrointestinal tract.

Gut Pathog. 6:38. doi: 10.1186/s13099-014-0038-9.  (Invited review)                       

Sinha S, Giri AK, Chowdhury R, Ray K. 2014 Mitochondrial genome variations among arsenic exposed individuals and potential correlation with apoptotic parameters.

Environ Mol Mutagen.  55:70-76                                                                   

Raghwan, Chowdhury R. 2014 Host cell contact induces Fur-dependent expression of virulence factors CagA and VacA in Helicobacter pylori.

Helicobacter.  19:17-25.          Selected as ‘Faculty of 1000 Prime’              

Chatterjee E, Chowdhury R. 2013 Reduced virulence of the Vibrio cholerae fadD mutant is due to induction of the extracytoplasmic stress response

Infect Immun. 81:3935-41                                                                                

Dey AK, Bhagat A, Chowdhury R. 2013 Host cell contact induces expression of virulence factors and VieA, a cyclic di-GMP phosphodiesterase, in Vibrio cholerae.

J Bacteriol. 195: 2004-10.                                                                                

Pradhan S, Mallick SK, Chowdhury R. 2013 Vibrio cholerae classical biotype is converted to the viable non-culturable state when cultured with the El Tor biotype.

PLoS One.  8:e53504.                                                                                                   

Chakraborti S, Bhattacharya S, Chowdhury R, Chakrabarti P. 2013 The molecular basis of inactivation of metronidazole-resistant Helicobacter pylori using polyethyleneimine functionalized zinc oxide nanoparticles. 

PLoS One.  8:e70776                                                                                        

Ghosh A, Choudhury ADas A, Chatterjee NS, Das T, Chowdhury R, Panda K, Banerjee R, and Chatterjee I.B. 2012. Cigarette smoke induces p-benzoquinone-albumin adduct in blood serum: Implications on structure and ligand binding properties.

Toxicology 292:78-89                                                                         

Ray S, Chatterjee E, Chatterjee A, Paul K, and R. Chowdhury. 2011 A fadD mutant of Vibrio cholerae is impaired in the production of virulence factors and membrane localization of the virulence regulatory protein TcpP.

Infect Immun.  79:258-66.                                                                                

Pradhan S, Baidya AK, Ghosh A, Paul K and  R. Chowdhury. 2010 The El Tor biotype of Vibrio cholerae exhibits a growth advantage in the stationary phase in   mixed cultures with the classical biotype.

 J Bacteriol. 192 :955-63.                                                                                 

Chatterjee A and R. Chowdhury 2008 Bile and unsaturated fatty acids inhibit the binding of cholera toxin and Escherichia coli heat labile enterotoxin to GM1 receptor. Antimicrob. Agents  Chemother     52: 220-224                                                                   

Chatterjee A., P.K. Dutta and R. Chowdhury. 2007.  Effect of fatty acids and cholesterol present in bile on expression of virulence factors and motility of Vibrio cholerae

Infect. Immun. 75: 1946-1953                                                                                      

Ghosh, A., K. Paul and R. Chowdhury 2006 Role of H-NS in colonization, motility and bile dependent repression of virulence gene expression in Vibrio cholerae.

Infect. Immun. 74: 3060-3064                                                                                      

Banerjee S., and R. Chowdhury. 2006 An orphan DNA (cytosine-5-)-methyltransferase n Vibrio cholerae.

Microbiology 152: 1055-1062                                                                        

Chatterjee, A., S. Chaudhuri, G. Saha, S. Gupta, and R. Chowdhury. 2004 Effect of bile on the cell surface permeability barrier and efflux system of Vibrio cholerae.

J. Bacteriol. 188: 6809-6814                                                                            

Paul, K., A. Ghosh, N. Sengupta and R. Chowdhury. 2004 Competitive growth advantage of non-toxigenic mutants in the stationary phase in archival cultures of pathogenic Vibrio  cholerae strains.

Infect. Immun. 72: 5478-5482                                                                                    

Krishnan, H. H., A. Ghosh, K. Paul and R. Chowdhury. 2004. Effect of anaerobiosis on expression of virulence factors in Vibrio cholerae.

Infect. Immun. 72: 3961-3967                                                                        

Sengupta N., K. Paul and R. Chowdhury. 2003 The global regulator ArcA modulates expression of virulence factors in Vibrio cholerae.

Infect. Immun. 71: 5583-5589                                                            

Mohanakumar K. P., B. Thomas, S. Sharma, D. Muralikrishnan, R. Chowdhury  

 and C. C. Chiueh. 2002.  Nitric Oxide: An antioxidant and neuroprotector.

Ann. N. Y. Acad. Sci. 962: 389-401

Chakrabarti S., N. Sengupta and R. Chowdhury. 1999. Role of DnaK in in vitro and in vivo expression of virulence factors of Vibrio cholerae.

Infect. Immun.   67 : 1025 – 1033.                                                                  

Gupta S. and R. Chowdhury. 1997 Bile affects production of virulence factors and motility of Vibrio cholerae.

Infect. Immun.   65 : 1131 – 1134.                                                                      

Sahu G.K., R. Chowdhury and J. Das. 1997. The rpoH gene encoding sigma 32 homolog of Vibrio cholerae.

Gene 189 : 203 – 207 

Sahu G.K., R. Chowdhury and J. Das. 1994. Heat shock proteins and heat shock protein antigens of V. cholerae.    Infect. Immun.   62 : 5624 -5631.                               

Biswas S.K., R. Chowdhry and J. Das. 1992. A 14 kilodalton inner membrane protein of V.  cholerae biotype El Tor confers resistance to Group IV infection to classical Vibrios.

J. Bacteriol. 174: 6221-6229.                                                                         

Chowdhury R., S.K Biswas. and J. Das. 1989. Abortive replication of choleraphage f 149 in the biotype El Tor of Vibrio cholerae.

J. Virol. 63 : 392-397                                                                                     

Chowdhury R., A., Sengupta P.Ray and J. Das. 1987.   Replication and packaging of

choleraphage f 149 DNA

J. Virol. 61 : 3999-4006

Chowdhury R. and J. Das. 1986. Infection by choleraphage f 138 : Bacteriophage DNA and replicative intermediates.J. Virol. 57 : 960-967

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